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THC and the Brain

THC affects neurons, "Nerve impulse-conducting cells" in the brain and has a definite impact on certain bodily functions. The brain communicates using neurotransmitters which lie between neurons using chemicals such as Serotonin, Epinephrine and Dopamine a Catecholamine neurotransmitter and hormone. THC mimics a natural neurotransmitter called Anandamide, sometimes referred to as the "Bliss Molecule" as it is a naturally occurring Cannabinoid which regulates mood, memory, appetite, pain, cognition and emotions and THC can interfere with these functions. THC binds with Anandamide and modifies the activity of several intracellular enzymes which also reduce the of neurotransmitters released. On the other hand, more Dopamine is released which is like a "reward" for your system.

The cannabis plant contains more than 421 chemicals of which 61 are cannabinoids. Interestingly, more than 2000 compounds are produced by pyrolysis during smoking of cannabis and they are represented by different classes of chemicals including nitrogenous compounds, amino acids, hydrocarbons, sugar, terpenes and simple fatty acids. These compounds altogether contribute to the unique pharmacological and toxicological properties of cannabis. delta 9-tetrahydrocannabinol is considered as the most psychoactive component contributing to the behavioral toxicity of cannabis. The aim of the current review is to discuss the properties of cannabinoids, primarily ?9_THC and its metabolites and the clinical implications thereof.


admin 09.02.2016 0 720
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09.02.2016 (409 days ago)
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